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Do you think it’s FOP?

Knowing it is fibrodysplasia ossificans progressiva (FOP) means getting the appropriate care and avoiding any interventions and treatments that might worsen the condition.1


Image from Pignolo RJ et al. Orphanet J Rare Dis 2011;6:8011*

The hallmark sign of FOP is shortened, turned-in big toes at birth2–4

Learn more

Useful links and resources

Browse our resources to learn more about FOP and find patient organizations and clinical trials.

Useful links and resources

Your healthcare team

Care for people living with FOP requires a coordinated approach from a range of medical specialties.5

Your healthcare team

*© 2011 Pignolo et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.   
1. Pignolo RJ et al. Orphanet J Rare Dis 2011;6:80. 2. Baujat G et al. Orphanet J Rare Dis 2017;12:123. 3. Pignolo RJ et al. J Bone Miner Res 2016;31:650–65. 4. Kaplan FS et al. J Bone Joint Surg Am 1993;75-A:220–230. 5. Kaplan FS et al. Proc Intl Clin Council FOP 2022;1:2–127.